Table 6 Genes significantly related to antibiotic resistance and their functions
Antibiotic | Gene | Hits | -log10(p value) | Average minor allele frequency | Average beta (effect size) | Function |
|---|---|---|---|---|---|---|
AMX | pbp1 A | 15 | 12.7 | 0.09 | 0.47 | Penicillin-binding protein 1 A |
VirD4 | 17 | 12.2 | 0.08 | 0.46 | Type IV secretion system | |
VirB11 (ptlH) | 8 | 11.2 | 0.08 | 0.46 | Type IV secretion system | |
lpxD | 3 | 10.9 | 0.07 | 0.456 | UDP-3-O-acylglucosamine N-acyltransferase | |
RluB | 7 | 10.0 | 0.07 | 0.47 | RNA pseudouridine synthase | |
LVX | gyrA | 21 | 8.7 | 0.28 | 0.33 | Type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner |
tlpC | 3 | 6.2 | 0.125 | 0.43 | Methyl-accepting chemotaxis transducer | |
CLR | 23S rRNA | 32 | 77 | 0.45 | 0.84 | Protein synthesis |