Table 4 Summary of pbp1 A mutations in H. pylori isolates

Known variants

V45I

0

12

17

94

0.369

V250I

0

10

17

96

0.354

F366L

11

10

6

95

2.6E-11

V374L

0

5

17

101

1

S402G

0

1

17

105

1

S414R

9

5

8

101

2.47E-06

S455 N

0

1

17

105

1

V469M

2

1

15

105

0.049

F473 V

11

11

6

95

2.91E-06

A474 T

0

7

17

99

0.59

D535 N

1

50

16

56

0.51

S543R

4

5

13

101

0.021

T556S

0

5

17

101

1

T558S

3

6

14

100

0.073

N562H/Y

3

2

14

104

0.018

T593 A/G/P/S

4

19

13

87

0.51

T593 A/G/P/S.T558S

2

1

14

106

0.044

G595S

2

20

15

86

0.73

G595_V596 insE

12

17

5

89

1.49E-05

D465_L466 insK

5

12

12

94

0.057

Novel variants

K315E

10

21

7

85

0.001

K464_D465 insK

4

1

13

105

0.001

D504 N

5

11

12

95

0.046