Table 1 Antibiotic resistance genes, resistance patterns, efflux resistance mechanisms and plasmids found in the Klebsiella pneumoniae pathogens from clinical and hospital effluent samples
From: Drug resistant Klebsiella pneumoniae from patients and hospital effluent: a correlation?
Isolate ID | Source of isolation | Resistance pattern | Resistance genes | Plasmid replicons | Efflux mechanism of resistance |
|---|---|---|---|---|---|
CKP1 | Clinical | CXM-CTX-TZP-TOB-CIP-SXT-TIG | blaTEM−206, blaTEM−141, blaTEM−1B, blaOXA−1, blaSHV−110, blaSHV−81, blaCTX−M−15, blaTEM−214, aph(6)-Id, aph(3’’)-Ib, aac(6’)-Ib-cr, sul2, dfrA14, qnrB1 | IncFIB(K), IncFIB(pKPHS1), IncFII(K) | Klebsiella pneumoniae KpnF, LptD, H-NS, emrR, Klebsiella pneumoniae KpnG, Klebsiella pneumoniae KpnH, marA, Klebsiella pneumoniae KpnE |
CKP2 | Clinical | CXM-CAZ-CTX-FEP-AMC-TZP-IPM-DOR-MEM-ERT-GEN-TOB-AMK-CIP-SXT | blaSHV−172, blaSHV−96, blaSHV−94, blaCTX−M−15, blaTEM−1B, blaOXA−181, blaNDM−1,, aac(3)-IIa, aph(6)-Id, aac(6’)-Ib-cr, aph(3’’)-Ib, aadA16, armA, aadA1, sul1, sul2, dfrA27, qnrS1, OqxB, OqxA, qacE | ColKP3, IncFIA(HI1), IncFIB(K), IncFIB(pNDM-Mar), IncFII(K), IncHI1B(pNDM-MAR), IncR, IncX3 | Klebsiella pneumoniae KpnE, Klebsiella pneumoniae KpnF, oqxA, cmlA5, qacEΔ1, AcrAB-TolC |
CKP4 | Clinical | CXM-CAZ-CTX-FEP-AMC-TZP-GEN-TOB-CIP-SXT-TIG | blaCTX−M−15, blaOXA−1, blaTEM−1B, aph(6)-Id, aph(3’’)-Ib, aac(3)-Iia, aadA16, aac(6’)-Ib-cr, sul2, sul1, dfrA27, OqxB, OqxA, qnrB6, tet(D), qacE | ColRNAI, IncFIB(K), repB(R1701) | Klebsiella pneumoniae KpnF, LptD, oqxA, tet(D), qacEΔ1, adeF, H-NS, AcrAB-TolC, CRP |
CKP5 | Clinical | CXM-CAZ-CTX-FEP-AMC-TZP-GEN-TOB-SXT | blaCTX−M−15, blaTEM−1B, blaSHV−172, blaSHV−96, blaSHV−94,blaSCO−1,, aadA16, aac(6’)-Ib-cr, aac(3)-Iia, aph(6)-Id,, aph(3’’)-Ib, sul1, sul2, dfrA27, OqxB, OqxA, qacE | IncFIA(HI1), IncFIB(K), IncFII(K), IncR | Klebsiella pneumoniae KpnE, Klebsiella pneumoniae KpnF, oqxA, LptD, qacEΔ1, adeF, Klebsiella pneumoniae KpnG |
CKP8 | Clinical | CXM-CAZ-CTX-FEP-AMC-TZP-IPM-DOR-MEM-ERT-GEN-TOB-AMK-CIP-SXT | blaCTX−M−15, blaTEM−1B, blaSHV−172, blaSHV−96, blaSHV−94, blaOXA−181, blaNDM−1, aac(3)-Iia,, aph(6)-Id, aph(3’’)-Ib, armA, aadA16, aac(6’)-Ib-cr, sul1, sul2, dfrA27, aadA1, qnrS1, OqxB, OqxA, qacE | ColKP3, IncFIA(HI1), IncFIB(K), IncFIB(pNDM-Mar), IncFII(K), IncHI1B(pNDM-MAR), IncR, IncX3 | Klebsiella pneumoniae KpnE, Klebsiella pneumoniae KpnF, oqxA, cmlA5, qacEΔ1 |
CKP10 | Clinical | CXM-CAZ-CTX-FEP-AMC-TZP-GEN-TOB-CIP-SXT-TIG | blaCTX−M−15, blaTEM−1B, blaSHV−172, blaSHV−96, blaSHV−94,,aac(3)-Iia, aph(6)-Id, aph(3’’)-Ib, aadA16, aac(6’)-Ib-cr, sul2, sul1, dfrA27, OqxB, OqxA, qnrB6, qacE | IncFIA(HI1), IncFIB(K), IncFII(K), IncR | OqxA, Klebsiella pneumoniae KpnE, Klebsiella pneumoniae KpnF, qacEΔ1, |
SEB1 | Effluent | AMC-TZP | blaSHV-1, OqxB, OqxA, tet(D) | IncFIB(K) | MdtQ, oqxA, marA, KpnEF, H-NS, adeF, KpnH |
SEB2 | Effluent | AMC-CTX-TZP | blaSHV-1, OqxB, OqxA, tet(D) | IncFIB(K) | MdtQ, oqxAB, marA, KpnEF, H-NS, adeF, KpnH |
SEB3 | Effluent | AMC-TZP-TIG | OqxB, OqxA, tet(D) | IncFIB(K) | MdtQ, oqxA, tet(D), H-NS, adeF, emrR, qacG, KpnEF, LptD, marA |
SEB4 | Effluent | AMC-TZP | blaSHV−1, OqxB, OqxA, tet(D) | IncFIB(K) | MdtQ, marA, tet(D), oqxA, KpnG, KpnEF |
SEB5 | Effluent | AMC-TZP | OqxB, OqxA, tet(D) | IncFIB(K) | MdtQ, oqxA, tet(D), H-NS, adeF, emrR, qacG, KpnEF, LptD, marA |
SEB6 | Effluent | AMC-TZP | blaSHV−1, blaSHV−187, OqxB, OqxA, tet(D) | IncFIB(K) | MdtQ, oqxA, tet(D), H-NS, adeF, emrR, qacG, KpnEF, |
SEB7 | Effluent | AMC-TZP | OqxB, OqxA, tet(D) | IncFIB(K) | MdtQ, oqxA, tet(D), H-NS, adeF, emrR, qacG, KpnEF, LptD, marA |
SEB8 | Effluent | AMC-TZP | OqxB, OqxA, tet(D) | IncFIB(K) | MdtQ, oqxA, tet(D), H-NS, adeF, emrR, qacG, KpnEF, LptD, marA |
SEB9 | Effluent | AMC-TZP | OqxB, OqxA, tet(D) | IncFIB(K) | MdtQ, oqxA, tet(D), H-NS, adeF, emrR, qacG, KpnEF, LptD, marA |
SEB10 | Effluent | AMC-TZP | blaSHV−1, OqxB, OqxA, tet(D) | IncFIB(K) | MdtQ, oqxA, tet(D), H-NS, adeF, emrR, qacG, KpnEF, LptD |