Fig. 6

The gut metabolome of silkworms and larvae associated with E. faecalis LX10 and N. bombycis. (a) KEGG pathway enrichment of the gut metabolites. (b) PLS-DA analysis of untargeted metabolomics data of healthy silkworm (CK), E. faecalis LX10 (EF, 107 CFU/mL), N. bombycis (NB, 109 spores/mL), and E. faecalis LX10 + N. bombycis (NF) group silkworms. Different processing times and groupings are visualized with different shapes and colours. (c) Pathway analysis of the identified differentially abundant metabolites in the CK, EF, NB, and NF groups. (d) Pathway impact resulting from the differentially abundant metabolites using MetaboAnalyst. The node color is based on the P values, and the node radius represents the pathway impact values