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Fig. 7 | BMC Microbiology

Fig. 7

From: Fingolimod as a potent anti-Staphylococcus aureus: pH-dependent cell envelope damage and eradication of biofilms/persisters

Fig. 7

Phospholipids inhibit antibacterial and bactericidal effects of Fingolimod. MICs and time-kill assay of Fingolimod against S. aureus SA113 (A) and (C), S. aureus CHS350 (B) and (D) were determined in the presence of exogenous phospholipids, including CL, PE, and PG. MIC Test: The concentrations of the three phospholipids were systematically varied from 0 to 128 μg/mL. This range was selected to comprehensively assess the dose-dependent influence of phospholipids on the MIC of Fingolimod against the two S. aureus strains. Time-kill assay: For the time-kill experiments, both SA113 and CHS350 cultures were adjusted to an initial density of 10⁸ (CFU/mL. Subsequently, they were treated with Fingolimod at a concentration of 4 × MIC, which was 12.5 μg/mL, and a fixed concentration of phospholipids at 64 μg/mL

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BMC Microbiology

ISSN: 1471-2180

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