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Fig. 1 | BMC Microbiology

Fig. 1

From: Fingolimod as a potent anti-Staphylococcus aureus: pH-dependent cell envelope damage and eradication of biofilms/persisters

Fig. 1

The bactericidal activity of Fingolimod against planktonic cells and persisters of S. aureus. Overnight cultures of MSSA SA113 (A) and MRSA CHS350 (B) were adjusted to 10⁸ CFU/mL and treated with 4 × MIC concentrations (Fingolimod: 12.5 μg/mL; vancomycin [MRSA only]: 2 μg/mL; cefazolin [MSSA only]: 2 μg/mL; linezolid: 2 μg/mL). Planktonic cell viability was quantified by CFU counts at 0, 3, and 24 h. And the MSSA SA113 (C) and MRSA CHS350 (D) incubated with 10 × MIC concentrations (Fingolimod: 32 μg/mL; vancomycin [MRSA only]: 5 μg/mL; cefazolin [MSSA only]: 5 μg/mL; linezolid:5 μg/mL). Planktonic cell viability was quantified by CFU counts at 24, 48, 72, 96 and 120 h for persisters. The negative control was DMSO. The data presented was the average of three independent experiments (mean ± SD)

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BMC Microbiology

ISSN: 1471-2180

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