Table 5 Frequency of resistance mechanisms and amino acid mutation sites in CROPA and MDR-CRPA

OprD mutations [39]

87.1% [40]

D43N, S57E, S59R, T103S, K115T, F170L, E185Q, P186G, V189T, E202Q, I210A, E230K, S240T, N262T, A267S, A281G, K296Q, Q301E, R310G, R310E, A315G.

100%

D43N, S57E, S59R, T103S, P109Q, K115T, F170L, V127L, E185Q, P186G, V189T, E202Q, I210A, E230K, S240T, N262T, A267S, T276A, A281G, K296Q, Q301E, R310E, G312R, A315G, L347M, G425A.

carbapenemase-producing [41]

12.7 -

81%

bla_GES, bla_KPC, bla_AIM, bla_GIM, bla_IMP, bla_NDM, bla_SPM, bla_VIM, bla_OXA.

0

-

higher Mex *¹ transcription levels [42]

28.8–72.9%

Transcription factor mutations in efflux pumps *²

MexR: P37R, L54P, Q55R, V126E, Q137H, G137P, C138A;

NalC: G71E, S209R; NalD: T158I [43].

NfxB: C199T, C113T [35].

MexS: N249D, V104A, F253L, D44E, S60F, F185L, L270Q, C245G, A166P, S60P, L263Q; MexT: G258D, Y138D, G258D [44].

MexZ: L138R, W176S, G195E [45].

0

Transcription factor mutations in efflux pumps

MexR: V126E, T130P; NalC: G71E, S209R; NalD: N130S.

NfxB: -.

MexS: -;

MexT: P202A, I298F, D302E.

MexZ: L142Q, R71W, A14V.