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Table 4 The MIC (mg/L) of P. aeruginosa for imipenem and meropenem

From: Loss of OprD function is sufficient for carbapenem-resistance-only but insufficient for multidrug resistance in Pseudomonas aeruginosa

MIC (mg/L)

pHERD20T IPM

oprD-pHERD20T

IPM

Fold Change

pHERD20T MEM

oprD-pHERD20T

MEM

Fold Change

PAO1

1

0.5

2

2

0.5

4

CROPA-01

8

0.5

16

2

0.5

4

CROPA-02

8

2

4

2

1

2

CROPA-03

8

0.5

16

4

0.5

8

CROPA-04

8

1

8

4

2

2

CROPA-05

16

0.5

32

8

0.5

16

CROPA-06

16

0.5

32

4

0.5

16

CROPA-07

16

0.25

64

2

0.5

4

CROPA-08

8

1

8

2

0.5

4

CROPA-09

8

0.5

16

2

< 0.125

> 16

CROPA-10

8

0.5

16

0.5

< 0.125

> 4

CROPA-11

16

0.25

64

4

< 0.125

> 32

  1. Note: Abbreviations in the table are listed here. The pHERD20T IPM represents the MIC against IPM after overexpression of the pHERD20T plasmid in P. aeruginosa. The oprD-pHERD20T IPM represents the MIC against IPM after overexpression of the oprD-pHERD20T plasmid in P. aeruginosa. The pHERD20T MEM represents the MIC against MEM after overexpression of the pHERD20T plasmid in P. aeruginosa. The oprD-pHERD20T MEM represents the MIC against MEM after overexpression of the oprD-pHERD20T plasmid in P. aeruginosa. Multiple of MIC represents the reduction in the MIC of oprD-pHERD20T over expression compared to pHERD20T for the same antibiotic
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BMC Microbiology

ISSN: 1471-2180

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