Table 4 Virulence Genes of APEC strain JS01

Adhesins

ECP

ykgK/ecpR, yagZ/ecpA, yagY/ecpB, yagX/ecpC, yagW/ecpD, yagV/ecpE

6

Hemorrhagic E.coli pilus

hcpA, hcpB, hcpC

3

Curli fibers

csgA, csgB, csgC, cgsD, cgsE, cgsF, csgG

7

E.coli laminin-binding fimbriae

elfA, elfC, elfD, elfG,

4

Adhesive fimbriae

cfaA, cfaB, cfaC, cfaD/cfaE

4

F9 fimbriae

fimA, Z_RS10335, ydeQ

3

Type 1 fimbriae

fimA, fimB, fimC, fimD, fimD, fimE, fimF, fimF, fimG, fimH, fimI, fimG

12

Stg fimbriae

stgA, stgC, stgB, stgD

4

AIDA-I type

ehaB, ehaA, aatA

3

UpaG adhesin, trimeric AT

upaG/ehaG

1

EaeH

eaeH

1

Z1307

ompA

1

Effector delivery system

TTSS secreted effectors

espR1, espL4, espX5, espL1(2), espX1

6

T6SS-II

clpV

1

T6SS

hcp1/tssD1, rhs/PAAR

2

Gsp

gspC, gspD, gspE, gspF, gspI, gspL, yghD

7

T2SS

gspG, gspH, gspK,

3

ETT2

ECs_3712(2), ECs_3715, ECs_3719, etrA, ygeG, ygeH, epaQ, epaO, escR, eprS

11

EHS

Z_RS01240, Z_RS01215, aec16, tssF

4

ACE T6SS

aec27/clpV, aec23, aec26, aec25, aec15, aec22, aec24, aec28, aec17, aec18, aec19, aec29

12

T4SS (plasmid 2 encode)

virB

1

Motility

Peritrichous flagella

fliA, fliD, fliE, fliF, fliG, fliH, fliI, fliJ, fliK, fliL, fliM, fliN, fliO, fliP, fliQ, fliR, fliS, fliT, fliZ, flgA, flgB, flgC, flgD, flgE, flgF, flgG, flgH, flgI, flgJ, flgK, flgL, flgN, flhA, flhB, flhC, flhD, flhe, cheA, cheB, cheR, cheW, cheY, cheZ, motA, motB, tar, flk

47

Biofilm

Cah, AIDA-I type

cah, cah

2

Antimicrobial activity/Competitive advantage

AcrAB

acrB

1

Exotoxin

Hemolysin/cytolysin A

hlyE/clyA

1

Immune modulation

Capsule

gndA

1

Invasion

Ibes

ibeB, ibeC

2

TraJ

AAA92657

1

Nutritional/Metabolic factor

Allantion utilization

allB

1

Enterobactin synthesis and transport

entA, entB, entC, entD, entE, entF, entS, fepA, fepB, fepC, fepD, fepE, fepG, fes

14

Salmochelin siderophore

iroB, iroC, iroD, iroE, iroN, sitA, sitB, sitC, sitD

9

Regulation

RcsAB

rcsB

1

PhoPQ

phoP

1