Table 3 Resistance Genes of APEC strain JS01

ABC antibiotic efflux pump

nitroimidazole

msbA

1

peptide

YojI

1

MFS antibiotic efflux pump

fluoroquinolone

emrA, emrB, emrR, mdtH,

4

tetracycline

emrY, tet(A)(2), tetC(2)

5

nucleoside, acridine dye, disinfecting agents and intercalating dyes

mdtN, mdtO(2), mdtP

4

Macrolide, aminoglycoside, cephalosporin, tetracycline, peptide, rifamycin

KpnE, KpnF

2

fosfomycin

mdtG

1

Fluoroquinolone, lincosamide, nucleoside, acridine dye, phenicol, disinfecting agents and intercalating dyes

mdtM

1

phenicol

floR

1

Tetracycline, benzalkonium chloride, rhodamine

mdfA

1

tetracycline

emrK

1

RND antibiotic efflux pump

Aminoglycoside, aminocoumarin

baeR, baeS, cpxA

3

aminoglycoside

acrD, mdtA, mdtB, mdtC

4

Macrolide, fluoroquinolone, penam

CRP, mdtE, mdtF, gadX

4

Fluoroquinolone, diaminopyrimidine, phenicol

rsmA

1

Fluoroquinolone, cephalosporin, cephamycin, penam

AcrE, AcrF

2

Fluoroquinolone, cephalosporin, glycylcycline, cephamycin, penam, tetracycline, rifamycin, phenicol, triclosan

AcrS

1

Fluoroquinolone, cephalosporin, glycylcycline, penam, tetracycline, rifamycin, phenicol, triclosan

acrB, acrA, acrR, marR

4

SMR antibiotic efflux pump

macrolide

emrE

1

ABC, MFS, RND antibiotic efflux pump

Macrolide, fluoroquinolone, aminoglycoside, carbapenem, cephalosporin, glycylcycline, cephamycin, penam, tetracycline, peptide, aminocoumarin, rifamycin, phenicol, triclosan, penem

TolC

1

Fluoroquinolone, cephalosporin, glycylcycline, penam, tetracycline, rifamycin, phenicol, triclosan

soxR, soxS

2

MFS, RND antibiotic efflux pump

Macrolide, fluoroquinolone, penam; tetracycline

evgA, evgS

2

Macrolide, fluoroquinolone, cephalosporin, cephamycin, penam, tetracycline

H-NS

1

RND antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams

Fluoroquinolone, monobactam, carbapenem, cephalosporin, glycylcycline, cephamycin, penam, tetracycline, rifamycin, phenicol, triclosan, penem

marA

1

β-lactamase

AmpC-type

Cephalosporin, penam

ampC1, ampH

2

EC-type

Cephalosporin

EC-14

1

TEM-type

monobactam; cephalosporin; penam; penem

TEM-135

1

Penicillin-binding protein mutations conferring resistance

Cephalosporin, cephamycin, penam

PBP3

1

Pmr phosphoethanolamine transferase

peptide antibiotic

eptA, PmrF, ugd

3

kdpDE

aminoglycoside

kdpE

1

Elfamycin resistant EF-Tu

elfamycin antibiotic

EF-Tu (2)

2

Antibiotic-resistant GlpT

fosfomycin

GlpT

1

Undecaprenyl pyrophosphate related proteins

peptide

bacA

1

Qnr

fluoroquinolone

QnrS1

1

Trimethoprim resistant dihydrofolate reductase dfr

diaminopyrimidine

dfrA14

1

The number in () indicates the number of coding genes annotated. The following table is the same