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Table 4 Evolutionary conservation analysis of amino acids in the RpoB gene-encoded protein

From: Adoption of an in-silico analysis approach to assess the functional and structural impacts of rpoB-encoded protein mutations on Chlamydia pneumoniae sensitivity to antibiotics

Amino acid change

Conservation score

Prediction

R421S

9

Highly conserved and exposed (F)

F450S

9

Highly conserved and buried (S)

S454F

9

Highly conserved and exposed (F)

L456I

9

Highly conserved and buried (S)

D461E

9

Highly conserved and exposed (F)

S476F

9

Highly conserved and buried (S)

L478S

9

Highly conserved and buried (S)

S519Y

9

Highly conserved and buried (S)