Table 4 Different categories of fecal microbiota transplantation and potential factors influencing AEs occurrence
Category | Sub-group | n (%) | AEs | Univariate | Multivariate | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|  | n (%) | χ2 | p value | OR | 95% CI | p value | ||||||
Sex | Males | 553 (68.0) | 30 (5.4) | 0.40 | 0.53 | 0.74 | 0.35–1.56 | 0.43 | ||||
Females | 260 (32.0) | 17 (6.5) | Â | Â | Â | Â | Â | |||||
Age group (mo) | < 36 | 101 (12.4) | 6 (5.9) | 0.005 | 0.94 | 2.05 | 0.73–5.8 | 0.18 | ||||
> 36 | 712 (87.6) | 41 (5.8) |  |  |  |  |  | |||||
Route of administration | Nasogastric tube | 50 (6.2) | 8 (16.0) | 10.21 | 0.000 | Â | Reference | Â | ||||
Nasal jejunal tube | 121 (14.9) | 17 (14.0) | 17.84 | 0.000 | 0.62 | 0.23–1.67 | 0.34 | |||||
Enema | 78 (9.6) | 5 (6.4) | 0.06 | 0.80 | 0.35 | 0.11–1.13 | 0.08 | |||||
Capsule | 525 (64.6) | 13 (2.5) | 29.72 | 0.000 | 0.09 | 0.03–0.27 | 0.000 | |||||
Colonoscopy | 39 (4.8) | 4 (10.3) | 1.51 | 0.22 | 0.47 | 0.12–1.90 | 0.29 | |||||
Donor selection | Consanguineous donors | 57 (7.0) | 13 (22.8) | 26.45 | 0.000 | 2.71 | 1.16–6.31 | 0.021 | ||||
Non-consanguineous donors | 756 (93.0) | 34 (4.5) | Â | |||||||||
Disease type | Chronic intractable diarrhea | No basic illness | 27 (3.3) | 0 (0.0) | 21.16 | 0.002 | 1.19 | 0.47–3.03 | 0.72 | |||
Primary immunodeficiency | 8 (1.0) | 2 (2.7) | Â | |||||||||
IPEX syndrome | 20 (2.5) | 5 (6.7) | ||||||||||
Gene mutation | 3 (0.4) | 0 (0.0) | ||||||||||
GVHD | 17 (2.1) | 1 (1.3) | ||||||||||
Non-chronic intractable diarrhea | 738 (90.8) | 39 (5.3) | ||||||||||
IBD | 76 (9.3) | 12 (15.8) | 15.42 | 0.000 | 3.98 | 1.78–8.92 | 0.001 | |||||
Non-IBD | 737 (90.7) | 35 (4.8) | Â | |||||||||
rCDI | 175 (21.5) | 11 (6.3) | 0.10 | 0.75 | 0.5 | 0.25 | 1.12 | |||||
Non-rCDI | 638 (78.5) | 36 (5.6) | Â | |||||||||