Fig. 2
From: Taurultam shows antiviral activity against SARS-CoV-2 and influenza virus
Taurultam protects mice and golden hamsters from nonlethal and lethal SARS-CoV-2 infection in vivo. (A) Flow chart of the mouse experiment. (B) Effects of taurultam on the body weights of mice infected with the SARS-CoV-2/C57MA14 strain. (C) Taurultam improved mouse survival. (D) Lung tissues of the mice from each group and the respective histopathological results (HE staining) and immunohistochemical results (viral NP staining) of the lung tissue sections. (E-G) Lung indices, pathology scores and NP-positive cell populations of lung tissues from the mice in each group. (H) Viral RNA copy numbers in mouse lung tissues and turbinates. (I) Flow chart of the in vivo experiments involving golden hamsters. (J) Effects of taurultam on the body weight of golden hamsters infected with the BA.2 strain. (K) Viral RNA copy numbers in nasal lavage fluid samples from golden hamsters. (L) Lung tissues of golden hamsters from each group and respective histopathological results (HE staining) of lung tissue sections. (M-N) Lung indices and pathology scores of the lung tissues of golden hamsters from each group. (O) Viral RNA copy numbers in lung tissues, turbinates and trachea from golden hamsters