Fig. 1
From: Taurultam shows antiviral activity against SARS-CoV-2 and influenza virus
Taurultam shows potent antiviral activity against different SARS-CoV-2 variants in vitro. (A) Chemical formula of taurultam. (B) Effects of taurultam on the activity of (B) Vero-E6, (C) Huh7, and (D) 293T cells in a series of concentrations. (C) The inhibitory effects of taurultam on (E) SARS-CoV-2/BJ01, (F) Delta, (G) XBB 1.9.1, and (H) BF.7 in the Vero-E6 cell line. (D-E) Taurultam decreased the number of viral RNA copies of SARS-CoV-2/BJ01, Delta, XBB 1.9.1, and BF.7 in the cell supernatants of the (D) Vero-E6 and (E) Huh7 cell lines. (F-H) The inhibitory effects of taurultam (30 µg/mL) and molnupiravir (20 µg/mL) on (F-G) NP protein expression and (H) viral RNA copy numbers of SARS-CoV-2 in the 293T-ACE2 cell line. Scale bars = 50 μm