Therapeutic potential of a newly isolated bacteriophage against multi-drug resistant Enterococcus faecalis infections: in vitro and in vivo characterization

Table 2 Comparison of phage ZAT1 to other enterococcus phages published in literature

Phage	Stability		Latent period (min)	Burst size (PFU/cell)	Host range (Spectrum)	Anti-biofilm Activity	Ex vivo and in vivo Analysis	Ref
Phage	pH	Temp.	Latent period (min)	Burst size (PFU/cell)	Host range (Spectrum)	Anti-biofilm Activity	Ex vivo and in vivo Analysis	Ref
SFQ1	5–11	50 °C	10	110	Broad	It effectively disrupts the biofilms formed by E. faecalis	Not determined	[95]
KEN04	3–11	-80 °C–37 °C	20	138.5	Broad	Significantly disrupted biofilms and reduced the bacterial population. It could not inhibit the biofilm formation	Not determined	[96]
HEf13	5–12	4–60 °C	25	352	Broad	Not determined	Effective against human dentin ex vivo infection model	[85]
IME-EF1	Not determined	Not determined	25	60	Moderate	Not determined	60% survival when administered 30 min after infection and 40% survival when administered 4 h after infection	[91]
φEF24C	--	--	30	110	Broad	Not determined	100% survival when administered 20 min after infection at MOI 0.01	[78, 92]
SRG1	3–11	37–65 °C	21	512	Narrow	Not determined	Not determined	[79]
SA14	6–9	4 °C -75°	20	20	Narrow	1.3 log cycles reduction after 2 h at MOI of 100 and reduced bacterial population	Not determined	[40]
ZAT1	5–10	4–65 °C	25	1263	Narrow	90% biofilm reduction and reduced bacterial population	100% survival when administered 1 h after infection at MOI of 0.1	This study

ISSN: 1471-2180