Fig. 9

Photomicrographs of cardiac tissues showing histopathological features of normal, infected, and treated mice. (A) Normal (negative control), displayed a normal architecture of the myocardium, as myocardium forms a thick middle layer between the outer (pericardium) and inner (endocardium) layers of the heart wall, with blood supplied via coronary circulation. (B) Positive (infected mice): showed degenerative changes (necrosis) and leucocyte infiltration (in sever state). (C) Treated group at MOI = 10 which show mild to moderate degenerative changes, mild leucocyte infiltration and mild necrosis. (D) Treated mice by phage at MOI = 1 which show mild degenerative changes with minimal leucocyte infiltration and mild necrosis. (E) Treated group at MOI = 0.1 which show moderate degenerative changes and mild to moderate leucocytic infiltration