Fig. 3

Changes in the Relative Abundance of Fungi in the Large Intestine After the Intake of Lp082. a Changes in the relative abundance of Lp082 in the large intestine on D1, D3, and D7. b,c α-diversity of gut fungi in the large intestine at different time points. The left panel shows the Shannon index, and the right panel shows the Simpson index. d Bray–Curtis dissimilarity of the large intestine fungal community between the three-time points in the Con group and the Tre group. Blue represents the Con group, and red represents the Tre group. There is no significant difference among the three-time points in the Con group, while there is a significant difference between D7 and the other two time points in the Tre group. e, f PCoA1 and PCoA2 of large intestine fungal community structure based on Bray–Curtis dissimilarity. g The fitted curve of the relative abundance changes of the single strain in the large intestine showed significant differences in relative abundance between the Con group and the Tre group. This strain exhibited a significant difference on D7. h Venn diagram showing the number of fungal species with significantly different (P < 0.05) in the large intestine and the small intestine. There is no overlap between the fungi with significant differences in the small intestine and the large intestine (i) Co-occurrence network of fungi and Lp082 in the large intestine based on Spearman correlation (P < 0.05, |R|> 0.4). In the network, the green nodes represent Lp082, the red nodes represent fungi positively correlated with Lp082, the blue nodes represent fungi negatively correlated with Lp082, the orange lines represent direct associations with Lp082, the solid lines represent positive correlations, and the dashed lines represent negative correlations. The thickness of the lines represents the strength of the correlation