Fig. 2

Changes in the Relative Abundance of Fungi in the Small Intestine After the Intake of Lp082. a Changes in the relative abundance of Lp082 in the small intestine on D1, D3, and D7. b,c α-diversity of gut fungi in the small intestine at different time points. The (b) panel shows the Shannon index, and the (c) panel shows the Simpson index. d Bray–Curtis dissimilarity of the small intestine fungal community between the three-time points in the Con group and the Tre group. Green represents the Con group, and brown represents the Tre group. There is no significant difference among the three-time points in the Con group, while there is a significant difference between D1 and the other two time points in the Tre group. e, f PCoA1 and PCoA2 of small intestine fungal community structure based on Bray–Curtis dissimilarity. g Heatmap showing the changes in the relative abundance of fungi with significant differences (P < 0.05) between the Con group and the Tre group in the small intestine on D1, D3, and D7. An asterisk (*) indicates fungi species with significant differences on the respective day. h Venn diagram showing the number of fungal species with significantly different (P < 0.05) in the small intestine on D1, D3, and D7. Two strains overlap between D3 and D7. i Co-occurrence network of fungi and Lp082 in the small intestine based on Spearman correlation (P < 0.05, |R|> 0.4). In the network, the green nodes represent Lp082, the red nodes represent fungi positively correlated with Lp082, the blue nodes represent fungi negatively correlated with Lp082, the orange lines represent direct associations with Lp082, the gray lines represent indirect associations with Lp082, the solid lines represent positive correlations, and the dashed lines represent negative correlations. The thickness of the lines represents the strength of the correlation