Fig. 7
From: Antimicrobial peptide AP2 ameliorates Salmonella Typhimurium infection by modulating gut microbiota
Changes in the microbiota caused by AP2 contributed to the protective effect of AP2 against ST infection. (a) Representative H&E-stained images of the cecum. Necrosis, erosion (red arrow) and marked neutrophilic infiltration (black arrow) were observed accompanied by atypical crypt microabscesses after 12 h of ST-inoculation in Control mice. Transfer of the microbiota from AP2 mice is sufficient to decrease ST-induced inflammation. (b) Left: A detailed scoring of cecal samples at 12 h post infection. Each stacked column represents an individual mouse. Right: Blinded histopathology scores of cecal samples. The score of individual mice (circles or boxes) and the geometric means for each group (bars) are indicated. ** represents p < 0.01